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While we understand that ineffective erythropoiesis, in concert with transfusion therapy, causes systemic iron overload in MDS-RS, the underlying pathophysiology of disturbed heme synthesis and mitochondrial iron accumulation is less well understood

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However, dysregulated mitochondrial apoptosis can accelerate disease progression (47)

[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Slominski A.T., Slominski R.M., Raman C., Chen J.Y., Athar M., Elmets C

Tocotrienols, for the most part, are not found in high levels in the diet