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PLoS One 18 , e0293676 (2023)

While the threshold DOAC concentration or activity which corresponds to a clinically important hemostatic defect is not known, expert consensus guidance suggests that levels above 30 ng/mL to 50 ng/mL are likely clinically significant (Table 1)14,20,21

Sex-related disparities in prevalence, risks, and mechanisms of SLD have been acknowledged for a long time but are not fully understood

doi: 10.3390/antiox11020232

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It has been shown that - and -tocopherols form short-chain metabolites, - and -carboxyethyl hydroxychroman and carboxymethylbutyl hydroxychroman, which substantially scavenge ROS and RNS in the cytosol [97]