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In this step, we cross-walk each no-volume MS-LTC-DRG to another MS-LTC-DRG for which we calculated a relative weight

Moreover, heme levels correlate with worse prognosis in sepsis patients and HO-1 has been shown to be protective in a murine sepsis model ( , these findings suggest that HO-1 limits the activation of non-canonical inflammasome signalling by modulating heme levels ( oxPAPC Oxidised 1-palmitoyl-2-arachidonoylsn-glycero-3-phosphoryl-choline (oxPAPC), a bioactive component of oxidised low-density lipoproteins, is a modulator of the inflammatory response (Meriwether et al., 2019)

It provides energy to immune cells and may positively impact the functionality of leukocytes during the acute phase response, a situation of high energy demand

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Site specific data reveals marked variability in approaches