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Topical vitamin B 12 has also been studied

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Hydroxocobalamin A long-lasting injectable form of B12, hydroxocobalamin is often used for B12 deficiency treatment in clinical settings

For example, sepsis increases the synthesis of coagulation factors such as fibrinogen and prothrombin, while the production of anticoagulants such as antithrombin and protein C is reduced or their functions are impaired, leading to sepsis-induced coagulopathy