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10.3389/fnana.2025.1580435 [DOI] [PMC free article] [PubMed] [Google Scholar] Kuhlmann T., Ludwin S., Prat A., Antel J., Brck W., Lassmann H

Furthermore, reactive astrocytes modulate acute neuroinflammation and repair the BBB in a CNS injury model, where their elimination resulted in impaired recovery

Samak DH, El-Sayed YS, Shaheen HM, El-Far AH, Onoda A, Abdel-Daim MM, Umezawa M

Abdullahi, Int

Interestingly, there is no known receptor for klotho, rather there is a coreceptor formed by shed klotho, FGFR, and FGF23, which indicates that shed klotho is an enzyme-dependent active scaffold protein