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Others warn against universal supplementation because of varying treatment responses, safety concerns over long-term use, and mixed outcomes in randomized controlled trials

Lotito SB, Frei B (2006)

This advice is especially crucial in the winter, when there is less sun exposure, and for expectant mothers who may have a reduced vitamin D balance

prepared LS of Clove EO by embedding casein using the freeze-thaw method and then coupled Campylobacter jejuni antibodies to the LS surface via the post-insertion method, producing protease-activated, antibacterial LS with bacterial targeting capabilities ( 6.4 Reducing the toxic effects of essential oil EOs are rarely applied directly to the skin without dilution because they may cause severe irritation

Therefore, we included a total of 87 articles in this study (eReference), and a flowchart is presented in eFig

1) Mechanistic gaps in non-classical pathways and tumor microenvironment (TME) crosstalk: Current research centers on classical ferroptosis regulators (GPX4, SLC7A11, and ACSL4) but overlooks the role of non-classical ferroptosis suppressors (FSP1, DHODH, and GCH1/BH4) in RCC