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In addition, we did not conduct metabolite analysis in tissues, especially in target organs, owing to the small sample size

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In humans, the HTMLA activity is partially compensated by serine hydroxymethyl transferase (SHMT) 1 and 2, while in mice, threonine aldolase (Tha1) is the primary source of HTMLA activity, but this gene is absent in humans [159].The liver and kidney are considered the primary organs involved in carnitine synthesis because of their considerable BBD activity

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