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Description

Saokham et al., 2018

RTA 408 inhibits interleukin-1-induced MMP-9 expression via suppressing protein kinase-dependent NF-B and AP-1 activation in rat brain astrocytes

Secreted ANGPTL3 binds lipoprotein lipase and inhibits its activity to hydrolyze lipoprotein triglycerides into fatty acids that are taken up by metabolic tissues

These combined effects reduce chronic inflammation and improve overall health in PTSD patients

Lelo A, Birkett DJ, Robson RA, Miners JO (1986) Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man