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In contrast, the diabetes mice resulted in only 0.08 0.03 and 0.15 0.02 nmol/mL following administration of a low and high dose sinigrin in Figure 5A

Disulfiram: DSF is a dithiocarbamate compound that treats alcohol dependence by targeting aldehyde dehydrogenase (ALDH), while acid condition reduces DSF to diethyldithiocarbamate (DTC) and invests the capacity to combine Cu(II) (Viola-Rhenals et al., 2018)

Med Chem 13:214225 Jalili-Baleh L, Forootanfar H, Kkkln TT, Nadri H, Abdolahi Z, Ameri A, Jafari M, Ayazgok B, Baeeri M, Rahimifard M, Abbas Bukhari SN, Abdollahi M, Ganjali MR, Emami S, Khoobi M, Foroumadi A (2018) Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimers disease based on coumarin and lipoic acid scaffolds

A protocol planned interim analysis was conducted for this cross-over study when 12 participants completed the first administration period (period 1), in order to re-assess the sample size based on the primary outcome data

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doi: 10.1016/j.foodchem.2016.05.074 139 PujiastutiD