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Rotenone is known to be a potent inhibitor of complex I of the mitochondrial respiratory chain in all cell types, by inhibiting the function of mitochondrial NADH dehydrogenase activity (Sherer et al ., 2003

Age-related increases in oxidative stress have been associated with chronic inflammation, cardiovascular and neurodegenerative disease, osteoarthritis and type 2 diabetes in humans (Reference Cannizzo, Clement and Sahu4Reference Rains and Jain6) and companion animals, namely cats (Reference Brown7,Reference Vite and Head8) and dogs (Reference Brown7Reference Pizzirani10)

Schmidt, K., Noureen, A., Kronenberg, F., & Utermann, G

It is essential to ensure that the patient knows how to properly administer insulin injections

Severe or persistent symptoms may require medical attention and should be reported to your healthcare provider. Patients with certain health conditions or on specific medications should always talk with their healthcare provider before starting B12 injections to avoid interactions and ensure the treatment is appropriate

doi: 10.1158/0008-5472.can-24-1412