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[17] While the FTC has always recognized that the smoking machine cannot accurately replicate human smoking and that no two human smokers smoke in the same way, the FTC did not initially recognize the tobacco industry's ability to design cigarettes that yielded low levels of tar and nicotine when machine-smoked, but yielded much higher levels when smoked by a human being

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It appears that smokers have an altered opioid flow all the time, when compared with non-smokers, and that smoking a cigarette further alters that flow by 20 to 30 percent in regions of the brain important to emotions and craving, David J

2015 Feb;17(2):256-8

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