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6.6.2 Gut microbiota-mediated biotransformation and mechanistic attribution 6.6.2.1 Microbial metabolic transformation pathways The gut microbiota functions as a metabolic organ, extensively biotransforming natural compounds into secondary metabolites with enhanced bioavailability and biological activity (242)

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PLoS One 9:e108024

ROS accumulation leads to metabolic abnormalities in RA-FLSs, with decreased mitochondrial oxidative phosphorylation and ATP reserve capacity but increased glycolytic activity in RA-FLSs, promoting RA synovial inflammation (106)

When stored at -20C, the active ingredients will remain effective for at least 2 months, but the integrity of the liposomes may be damaged when frozen for more than 2 months

Jian S, Yang K, Zhang L, Zhang L, Xin Z, Wen C, et al