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Type of study: non-rct in vitro Number of citations: 15 Year: 2023 Authors: Ying-Yin Zhu, Wuqing Xiao, Wanling Zhong, Chen Xi, Jinhong Ye, Qing Zhang, Huichao Wu, Shouying Du Journal: International journal of pharmaceutics Journal ranking: Q1 Key takeaways: The combined system of Cur-Lips and skin-penetrating peptide TD-1 effectively promotes skin penetration and has great potential for melanoma prevention and treatment

Supports DNA Repair & Cellular Health Aids in reducing oxidative stress and supporting tissue renewal

Experimental studies in animal models and in vitro systems suggest that DSIP can influence the release of hormones such as growth hormone, luteinizing hormone, and adrenocorticotropic hormone through both hypothalamic and pituitary-level mechanisms [8]

Some Phase 3 trial sites are in Asia (REDEFINE 5, REDEFINE 6) but no regulatory approvals have been announced as of June 2026

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Urinary 6-sulfatoxymelatonin, a melatonin metabolite, increased 1.6-fold compared to placebo