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The key difference is that retatrutide provides triple agonism (GLP-1 + GIP + glucagon) while semaglutide provides only GLP-1 agonism

References [1] Pejman S, Kamarehei M, Riazi G, Pooyan S, Balalaie S

This causes your skin to wrinkle and sag and your muscles, bones, and tendons to shrink, stiffen, and get weaker

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Signs of Irregular Periods Related to Semaglutide Missed or Delayed Periods: The passage of some women taking Semaglutide may note that their menstrual cycles are not coming regularly or on time

Individuals with certain allergies, liver conditions, or kidney disease, or those who are pregnant or nursing, should consult a physician before starting any injection protocol