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Recipients with antibody-mediated rejection exhibit reduced gut microbial richness and diversity, accompanied by significant changes in key metabolites, such as 3-hydroxy-5-cholic acid and taurocholic acid, both of which correlate strongly with microbial compositional shifts [168]

In case of treatment failure, hyperbaric O 2 is considered

The active caspase-1 converts pro-IL-18 and pro-IL-1 into IL-18 and IL-1, which further induces an inflammatory response and triggers pyroptosis [74, 88]

Chu B, Kon N, Chen D, Li T, Liu T, Jiang L, Song S, Tavana O, Gu W (2019) ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

Gut 2013;62:178794

Although the use of exosomes as a delivery system has its drawback (for example, quickly eliminating by the reticuloendothelial system, lack of efficient encapsulation methods, and potential immune responses), exosomes targeted at tumors may allow systemic administration of miRNA as cancer treatment and are thus worthy of attention