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Key points A combination of spirochaetal and host genetic factors shape the outcome of Lyme arthritis, which ranges from mild, antibiotic-responsive joint inflammation to persistent, antibiotic-refractory autoinflammatory or autoimmune synovitis

The fragment ion spectra were recorded at a resolution of 15,000, with a dynamic exclusion window of 20 secs

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Preclinical and in silico studies highlight compounds like resveratrol, curcumin, and epigallocatechin gallate for their neuroprotective effects and interaction with key Alzheimer's disease related targets