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Furthermore, EGCG has inhibitory effects on the proliferation and invasion of lung cancer cells in vitro (Jin et al., 2015)

Rotenone is a natural compound found in plants and has been used as a pesticide

However, in most cases, PKM2 is gradually replaced by other PK isoforms during tissue growth (109)

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At present, the commonly used analgesic drugs in clinical practice are opioid analgesics and non-steroidal anti-inflammatory drugs, which often lead to dependence and addiction