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Glucose-stimulated insulin secretion Glucose-stimulated b-cell insulin release is the primary mechanism of insulin regulation ( Figure 3 ) (35, 88).In humans, this is illustrated by use of the hyperglycemic clamp technique ( Figure 5 ), in which individuals are made rapidly hyperglycemic by injection of intravenous dextrose, and hyperglycemia is maintained by variable rate dextrose infusion at a predefined target glucose (20)

Therapeutic consequences of targeting the IGF-1/PI3K/AKT/FOXO3 axis in sarcopenia: a narrative review

Biomedical and Pharmacology Journal, 11 (3)

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