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Li S, Liu X, Chen X, Bi L (2020b) Research progress on anti-inflammatory effects and mechanisms of alkaloids from Chinese medical herbs

In the brain, regular moderate-intensity running exercise (13 m/min 50 min/day, 2 weeks) induces myokine IL-6, which elevates hypothalamic expression of MOTS-c/-END in proopiomelanocortin (POMC) neurons [148]

7.3 Targeting FSP1/CoQ 10 pathway Intrastriatal administration of CoQ 10 showed higher efficacy in exerting neuroprotective effects than oral CoQ 10 delivery in a rat PD model, requiring 17,000 times lower dose (241)