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The mechanism involves PD-1-mediated induction of GATA1 binding to the Plpp1 promoter in CD8 + T cells, resulting in the suppression of Plpp1

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Use in Children: Experience with oral valproate has indicated that children under the age of two years are at a considerably increased risk of developing fatal hepatotoxicity, especially those with the aforementioned conditions (see Hepatotoxicity as previously mentioned)

[DOI] [PMC free article] [PubMed] [Google Scholar] 917.Tuleta I., Frangogiannis N.G

Thus the term "intracellular signaling domain" refers to the portion of a protein that transduces the effector function signal and directs the cell to perform a specialized function