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3.1.2 In vivo animal studies It is known that stress negatively influences the homeostasis of the circadian rhythm, which results in disturbance of the hypothalamic-pituitary-gonadal axis

Mitochondrial functions and homeostasis maintenance Mitochondrial functions Mitochondria are energy-producing cellular organelles that generate energy in the form of ATP via oxidative phosphorylation (OXPHOS) performed by the electron transport chain (ETC) complexes

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The data of 11 antioxidant biomarkers were obtained from the open database by the most up-to-date Genome-Wide Association Studies (GWAS), the summary statistics of PD and ALS were obtained from the International Parkinsons Disease Genomics Consortium (IPDGC) (33,674 cases, and 449,056 controls), and the International Amyotrophic Lateral Sclerosis Genomics Consortium (IALSC) (20,806 cases and 59,804 controls), respectively