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doi: 10.1016/j.biopsycho.2011.02.002 427 HannibalKEBishopMD

F.Lopez MolinaM.et al (2015)

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4 Molecular mechanisms of the activation of pro-inflammatory response caused by bacterial invasion Dysbacteriosis of the gut microbiota can lead to disruption of intestinal barrier function and immune homeostasis

The more recent SURMOUNT-5 trial directly compared tirzepatide to semaglutide and found tirzepatide superior , with 20.2% weight loss versus 13.7% for semaglutide at 72 weeks