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Indeed, the active site cysteine, Cys-215, was identified by MS/MS as the major site of acrolein adduction, while histidine-214 of the active site showed only little reactivity towards acrolein [123]

Hooper, D

Conversely, excessive accumulation can induce toxicity, trigger nutritional imbalances, and exacerbate oxidative stress

Glycolysis inhibition In the dysregulated substrate flux and redox imbalance during ischemic stroke (metabolic chaos), the brains compensatory shift toward anaerobic glycolysis (a Warburg-like adaptation) initiates a pathogenic cascade: lactate accumulation drives cytotoxic acidosis while concurrently fueling enzymatic lipid peroxidation, demanding targeted strategies to modulate this maladaptive energetic response [133, 207]

The role and possible mechanism of the ferroptosis-related SLC7A11/GSH/GPX4 pathway in myocardial ischemia-reperfusion

Activated neutrophils release PAD enzymes that promote citrullination of synovial tissue