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26 Phentolamine (an alpha-adrenergic blocker) and papaverine (a nonspecific phosphodiesterase inhibitor) both act as vasodilators and may be used in combination with alprostadil if the patient has an inadequate response to alprostadil alone

There are, however, some conflicting data in elderly patients suggesting that the PPI use for more than 12 months or even after treatment for up to 7 years does not increase the risk of vitamin B12 deficiency (Maes, Fixen, and Linnebur 2017

Table 2 includes orthologs of proteins and polypeptide molecules or portions thereof comprising nucleic acid sequences having at least 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 99.5% or more identity over their entire length to nucleic acid sequences of any of the publicly available sequences listed in table 2

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