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These side effects are minimal with intranasal administration

Briefly, 20K NHDF cells in 100 L of media were plated in each well of a 96-well plate and incubated overnight at 37C, 5% CO 2

Orthopedics 35(3):213-217

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Additionally, DA quinones can be oxidized to aminochrome, whose redox-cycling leads to the generation of the superoxide radical and the depletion of cellular nicotinamide adenine dinucleotide phosphate-oxidase (NADPH), which ultimately forms the neuromelanin (Sulzer et al., 2000) known to be accumulated in the SNpc of the human brain (Ohtsuka et al., 2013, 2014