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Inhibition of 1CM by methotrexate blocked roxadustat-mediated protection against ROP, demonstrating that increased serine/1CM participates in protection induced by roxadustat

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Cell 169(7):1327-1341.e23, 2017

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were able to show decreases in inflammatory biomarkers, such as D-dimer and ferritin, in patients who had a 1-g dose of oral vitamin C given every eight hours in addition to standard treatment, but their sample size was only 17 patients and there was no true control group to compare results to said standard treatment alone [55]