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Joint hyperextensibility occurs in more than two-thirds of AD-HIES patient and may contribute to the high frequency of degenerative bone disease [12]

Funding This study was supported by grants from the National Key R&D Program of China (2021YFA1100600 and 2022YFA0807300), National Natural Science Foundation of China (82202032, 81930085 and 32150710523), Jiangsu Province International Joint Laboratory for Regenerative Medicine Fund, Suzhou Foreign Academician Workstation Fund (SWY202202) and Suzhou Science and Technology Initiative Fund (SYS2020087)