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10.5056/jnm16001 J

Muldoon LL, Walker-Rosenfeld SL, Hale C, Purcell SE, Bennett LC, Neuwelt EA

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Although lung transplantation remains the most effective treatment, its clinical application is limited by donor scarcity, and existing pharmacological interventions provide only modest antifibrotic efficacy

The GSH/GSSG redox couple is considered the main cellular redox buffer and, as such, the concentration ratio between reduced and oxidized forms of the tripeptide ([GSH]/[GSSG] ratio) is often used as an indicator of the cellular redox state (Wu et al., 2004)