oral administration of glutathione: bioavailability in rat pancreas Frontiers Frontiers | Sulforaphane in cancer

Third, the causal relationship between ferroptosis and stone pathogenesis lacks rigorous validationexisting data only confirm oxalate induces ferroptosis, but it remains unclear whether ferroptosis directly promotes crystal adhesion, tubular injury, or inflammatory responses (key steps in stone formation) or is merely a secondary consequence of oxalate toxicity

Therefore, although the concept of FMT is highly attractive, its large-scale clinical application still needs to resolve key issues such as donor screening, preparation standardization, elucidation of mechanisms, and long-term safety assessment (Table 2)

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Furthermore, dietary adjustments, such as the adoption of a Mediterranean diet rich in antioxidants, omega-3 fatty acids, and polyphenols, may have a positive impact on mitochondrial health [179, 180]

doi: 10.1038/nrmicro1385

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