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Masubuchi Y, Bourdi M, Reilly TP, Graf ML, George JW, Pohl LR

4.3 Antioxidants in chemotherapy 4.3.1 Impact on chemotherapy-induced lipid peroxidation One of the important treatments for cancer, which is commonly known as chemotherapy, causes severe oxidative stress on normal tissues, and there is increased lipid peroxidation [136]

Folding the mitochondrial UPR into the integrated stress response

The clonal evolution model suggests that cumulative genetic and epigenetic alterations drive tumor progression, whereas the cancer stem cell model posits that a subset of tumor-initiating cells sustains growth and therapeutic resistance