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Hepatocyte hyperproliferation upon liver-specific co-disruption of thioredoxin-1, thioredoxin reductase-1, and glutathione reductase

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This increased P-450 activity, as you might expect, results in an increased formation of NAPQI from the acetaminophen

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[DOI] [PMC free article] [PubMed] [Google Scholar] 113.Waxman DJ, OConnor C

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