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Clofarabine, Idarubicin, and Cytarabin (CIA) As Frontline Therapy for Patients Younger Than 61 Years with Newly Diagnosed Acute Myeloid Leukemia (AML)

Reduced GH/IGF-I secretion in the elderly is believed to be responsible for or contribute to many symptoms of aging, including loss of muscle mass, increased adiposity, reduced bone mineral density, and decline in energy levels, along with alterations in psychological indicators of the quality of life[237]

10.1002/ijc.29642 133 QuailD.JoyceJ

For that reason we assumed there was a close relationship between the asthma immunological mediators and the antioxidant system in these patients

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By 2020, DON had advanced through phase III clinical testing in more than 700 patients, but dose-limiting gastrointestinal toxicity and limited efficacy curtailed further development [167]