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13,14 In contrast, although our study showed that patients who had immune-related adverse events received a significantly higher median number of checkpoint inhibitor doses compared with patients without such adverse events, the number of checkpoint inhibitor doses received did not significantly predict the occurrence of immune-related adverse events

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It is worth noting that the complex inflammatory milieu results from the synergistic activity among different immune cell populations rather than a single role

Nutrients 15 , 2265 (2023)

[213] Edaravone yields a significant (33 %) functional improvement in ALS patients as measured by the revised ALS Functional Rating Scale, [214] although it is unclear how this impacts patient survival time overall

Oxidative stress results from a disturbance in reactive oxygen species (ROS, such as singlet oxygen, hydrogen peroxide, hydroxyl radicals, and superoxide) production and/or degradation leading to an oxidant-antioxidant imbalance, and accompanies the primary mechanical impact in the TBI model