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Frontiers of Environmental Science & Engineering, 10(1), 168176

Charting, navigating, and populating natural product chemical space for drug discovery

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At week 15, rats were sacrificed to assess liver/body weight ratio, degree of liver fibrosis (Masons trichromic) and steatosis (oil red), and plasma endotoxin, IL1- and TGF- levels (ELISA) Results: All NASH rats increased in body weight, whereas liver/body weight ratio normalized in group 2

neuronal signaling efficiency mitochondrial membrane stability oxidative resilience cellular communication Because the brain contains a very high concentration of membranes relative to other tissues, membrane lipid balance becomes especially important for neurological function