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Arch Neurol 64(7):938944 Strijks E, Kremer H, Horstink M (1997) Q10 therapy in patients with idiopathic Parkinsons disease

3 Every time the brain worksthinking, focusing, processing, rememberingthat activity generates its own byproduct: oxidative stress

Temporary S-glutathionylation of enzymes in the TCA cycle, ETC, or -oxidation pathway protects them from irreversible oxidation when ROS is high but may also hypothetically serve as a mechanism to diminish mitochondrial ROS production by reducing their activity [51]

A total of eight members of the GPX family are currently found, namely GPX1-GPX8

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