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Although there have been many theories of how it works, plausible mechanisms of action include increasing pelvic musculature tone and awareness either through a local effect on the pelvic nerves or the brain

Abstract Background: Parkinsons disease (PD) is a multifactorial, progressive neurodegenerative disorder that primarily affects dopaminergic neurons in the substantia nigra

doi: 10.1186/s12974-019-1524-2 138 ButlerT

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Escherichia coli Nissle 1917 (EcN), a Gram-negative, non-lactic acid probiotic strain, can colonize the gut stably, interact with IECs and resident microbes, and exert protective effects