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The treadmill training protocol was performed for 1 h daily on an EXER-4 treadmill (Columbus Instruments, Columbus, OH, United States) as described before ( At the end of the training period, the animals were sacrificed, and the liver and kidneys were quickly excised from the animals and stored immediately at 80C until further analysis (within 1 week)

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Concurrent alcohol abuse and smoking significantly increased the percentage of the glutathione pool present as GSSG

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Most recently, a double-blinded, randomized, placebo-controlled phase IIa study in patients with refractory chronic cough with an alkaline hypertonic divalent salt pH 9 aerosol (SC0023) confirmed the treatment efficacy results of the exploratory trial, while further reporting a reduction in daily cough rate for patients with heavy cough (19 coughs h 1 ) exceeding 70% relatively to baseline up to 3 weeks post-treatment (NCT07003347)