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However, side effects can still occur

10.4061/2010/823710 53 KaganJ

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This study supports the idea that, in cases where maximizing B12 uptake is crucial, adopting an empty stomach strategy might be a beneficial approach

Even more people have nutrient inadequacies---when intake of a nutrient is above the level usually associated with deficiency but below the estimated average requirement for healthy individuals---suggesting a potential for marginal deficiencies

They found that arginine increases growth hormone, but they will need to do more studies to explore this effect