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2.5.1 Multi-omics approaches and systems biology in Alzheimers research Recent advances in multi-omics technologiesincluding transcriptomics, metabolomics, proteomics, and spatial transcriptomicshave opened new avenues for elucidating the molecular mechanisms through which natural products influence AD pathogenesis (Ma et al., 2024a)

Treatment with GH antagonists or somatostatin analogs, as well as genetic disruption or pharmacological blockade of the GHR, resulted in amelioration of experimental diabetic nephropathy, including normalization of diabetes-associated renal hypertrophy and glomerular enlargement, as well as albuminuria [203, 207,208,209,210]