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The results directly indicated that the targeting motif RGD-binding peptide RGD-GHK almost totally suppressed the collagenase (MMP-1) expression, resisted H 2 O 2 -induced COL-1 degradation, and simultaneously promoted collagen synthesis compared with GHK alone for cell anti-aging performance

2003;284:C16691677

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p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice

However, excessive ROS formation can offset these protective mechanisms during intense and exhaustive exercise