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[DOI] [PubMed] [Google Scholar] 37.Pan H, Chen J, Shen K, Wang X, Wang P, Fu G

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This phenomenon is generalisable to mammalian modelsthe mRNA expression of BRCA1 and H2AX, key DNA damage repair genes, are synchronously reduced when the primordial follicles of the ovaries of young (~ 9-week-old) and old (32-week-old) rats are compared, further validating the systematic decline in DNA repair efficiency during reproductive ageing [37, 38]

The Phase 3 TRIUMPH-4 ran for 68 weeks