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The canonical inflammasomes are activated by the nucleotide-binding oligomerization domain (NOD) of the leucine-rich repeat (LRR)-containing protein (NLR) family members NLRP1, NLRP3, NLRC4, NLRP6, NLRP7, NLRP9b, the absent in melanoma 2 (AIM2)-like receptor (ALR) AIM2 and Pyrin [323,324,325,326]

VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1

Invest 131 (19), e148288

Researchers proposed a nanosystem (ACF-MnO 2 ) composed of MnO 2 nanoparticles and ACF, which increased the content of oxygen in tumors, inhibited HIF-1 function, and improved RT efficiency by downregulating PD-L1