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Immunologic profiles of persons recruited for a randomized, placebo-controlled clinical trial of hookworm infection

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10.1056/nejmc2004973 [DOI] [PMC free article] [PubMed] [Google Scholar] Vignardi C

doi: 10.1016/j.pneurobio.2020.101892

Although moderate exposure to fatty acids increased apoB100 secretion, prolonged exposure leads to ER stress and posttranslational degradation of apoB100, and consequently decreased apoB100 secretion, both in vivo and in vitro hereby linking ER stress to NAFLD progression through apoB100 inhibition [114, 115] (Fig

224,225,226 Macroautophagy, the main subtype, is primarily regulated by mTORC1 for activating the unc-51-like autophagy activating kinase 1 (ULK1) complex and dephosphorylating transcription factor EB (TFEB) to induce autophagy