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Unlike vitiligo, it is not an active destruction but a gradual reduction in the functionality of melanocytes

This autonomic disturbance occurs relatively early in the disease course, affecting approximately 11.7% of patients at enrollment in clinical studiesexceeding the prevalence of diarrhea (2.4%) or unintentional weight loss (3.1%)

Choi, R., Park, W., Chun, G., Lee, S

Excess vitamin A appears to interfere with vitamin K absorption, whereas vitamin E may inhibit vitamin K-dependent carboxylase activity and interfere with the coagulation cascade (129)

All study participants gave written consent to use their data in an anonymized form for research purposes before taking part in this study