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Synergistic Stimulatory Effect of 12-O-Tetradecanoylphorbol-13-Acetate and Capsaicin on Macrophage Differentiation in HL-60 and HL-525 Human Myeloid Leukemia Cells

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The critical role of Gpx4 is underscored by the fact that whereas Gpx1-knockout mice are fully viable, Gpx4-knockout animals demonstrate embryonic lethality, and Gpx4 +/ cell lines are markedly sensitive to inducers of oxidative stress, including -irradiation, tert -butyl-hydroperoxide, and hydrogen peroxide, as compared with cell lines derived from wild-type control littermates (147)

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