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Methylfolate helps power the methylation cycle, which regulates: Homocysteine metabolism Neurotransmitter production (serotonin, dopamine, norepinephrine) Hormone regulation Detoxification and antioxidant production DNA synthesis and repair When the MTHFR gene has a variant (like C677T or A1298C), the enzyme works less efficiently

Additionally, carbon units for the folate cycle can also be derived from formate, which can donate one carbon directly to tetrahydrofolate in a reversible reaction catalyzed by the tri-enzyme Methylenetetrahydrofolate Dehydrogenase, Cyclohydrolase, and Formyltetrahydrofolate Synthetase 1 (MTHFD1)

In animals, unlike the deletion of Slc7a11 , the deletion of the GGT family member Ggt1 results in increased GSH levels in urine, reduced cysteine levels in tissues and perinatal lethality 24

Ethics declarations Competing interests The authors declare no conflict of interest

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