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Endocrinology (2002) 143:453643

In addition, compared with non-diabetic mouse kidneys, diabetic mouse kidneys showed increased iron content, decreased p-AMPK/t-AMPK, increased ROS formation, increased expression of NADPH oxidase subunit-gp47 phox , increased MDA expression, and decreased expression of SOD, CAT, and GSH-PX, as well as decreased expression of GPX4

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In this study, myosteatosis was associated with poorer OS and PFS in patients treated with PD-1 inhibitor plus tyrosine kinase inhibitors, but showed a protective effect on PFS in those receiving PD-1 plus CTLA-4 blockade, potentially due to differences in immune cell composition and checkpoint expression within the TME [141]