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Description

Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments

Rate of absorption (K a ) determines the time required for the administrated drug to the reach an effective plasma concentration and may, thus, affect the onset of drug effect

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Statements Author contributions CX: Conceptualization, Writing original draft

Objective: Here, we investigated whether histone deacetylase 8 (HDAC8) contributes to tight junction (TJ) disruption in AR by modulating Smad7 acetylation