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As with many other disorders, factors such as nutritional status, neurotransmitter metabolites, oxidative stress, and environmental influences affect the metabolic profile in ASD (Zurawicz et al

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Furthermore, the relative abundance of Akkermansia , a genus positively associated with improvements in obesity-related metabolic issues 60 , was increased in the vehicle-treated group that underwent diet switch relative to the WD control group, suggesting a potential for distinct microbiome-mediated mechanisms of weight loss subsequent to diet switch from those of diet switch in combination with 5A-1MQ treatment