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Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species

It seems likely that oxidative stress activates various transcription factors (NF-B, AP-1, p53, HIF-1, PPAR-, -catenin/Wnt and Nrf2) leading to the abnormal expression of certain genes , including those governing growth factors, inflammatory cytokines and cell cycle regulatory molecules (11)

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Nascent ROS and damaged molecules are addressed by high capacity scavenging and repair systems that draw electrons from either NADPH or PET coupled to stromal redox proteins [5,6,7,8]